Protein Structure, Function and Folding

Protein Structure, Function and Folding
A Symposium to Honor the Life and Work of Paul B. Sigler
May 4 & 5, 2001

PROGRAM

Friday, May 4, 2001

12:30-1:30 p.m. Registration and Reception
Lobby, Davies Auditorium, 15 Prospect Street

1:45 p.m. Welcome - Thomas A. Steitz, Yale University
Davies Auditorium, 15 Prospect Street

2:00 p.m. Convene Session I - Greg Van Duyne, Session Chair

2:15 - 2:45 p.m. Structure and Mechanism in G protein Signaling
Steve Sprang, University of Texas Southwestern Medical Center

2:45 - 3:15 p.m. The Structure of trp Repressor in an Inebriated State
Catherine Lawson, Rutgers University

3:15 - 3:45 p.m. The Multifunctional Arginine Repressor
Greg Van Duyne, University of Pennsylvania School of Medicine

3:45 - 4:15 p.m. Coffee Break

4:15 - 4:45 p.m. Proteins Off, On and Around DNA
Brian Matthews, University of Oregon

4:45 - 5:15 p.m. DNA Target Discrimination by Papillomavirus E2 Proteins
Rashmi Hegde, Skirball Institute for Biomolecular Medicine

5:15 p.m. Adjourn Session I

6:00 p.m. Cocktails/Buffet Dinner
Omni Hotel, 155 Temple Street

Saturday, May 5, 2001

8:30 a.m. Buffet Continental Breakfast
Lobby, Davies Auditorium, 15 Prospect Street

9:00 a.m. Convene Session II - Andrzej Joachimiak, Session Chair

9:15 - 9:45 a.m. HIV-1 Integrase. The Third Enzyme of HIV
David Davies, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

9:45 - 10:15 a.m. Dynamic Features of PKA Structure and Localization
Susan Taylor, University of California, San Diego

10:15 - 10:45 a.m. Significance of Being Precise in Crystallography
Zbyszek Otwinowski, University of Texas Southwestern Medical Center

10:45 - 11:15 a.m. Coffee Break

11:15 - 11:45 a.m. X-rays with Brilliance and Bang: 3rd Generation Synchrotrons in the Post Genomic Era
Andrzej Joachimiak, Argonne National Laboratory

11:45 - 12:15 p.m. Protein Structure by High Resolution Electron Microscopy
Richard Henderson, MRC Laboratory of Molecular Biology

12:30 p.m. Lunch
Yale Commons, 168 Grove Street (enter through Woolsey Hall)

2:00 p.m. Convene Session III - Joe Noel, Session Chair

2:15 - 2:45 p.m. Ideas as to Why Our Brain Tires in the Evening
Steve McKnight, University of Texas Southwestern Medical Center

2:45 - 3:15 p.m. Structural and Functional Basis for Plant Biosynthetic Cascades Involved in Stress Responses
Joe Noel, The Salk Institute for Biological Studies

3:15 - 3:45 p.m. Structure and Function of Phospholipase A2
Edward Dennis, University of California, San Diego

3:45 p.m. Coffee Break

4:15 - 4:45 p.m. Prion Proteins -- A New Paradigm in Genetics
Susan Lindquist, University of Chicago

4:45 - 5:15 p.m. GroEL-Mediated Protein Folding
Arthur Horwich, Yale University

5:15 p.m. Adjourn Session III

6:30 p.m. Cocktails
Lorrico Ballroom, Yale Room, LoRicco Building, 216 Crown Street

7:30 p.m. Banquet
Lorrico Ballroom, LoRicco Building, 216 Crown Street
Personal Reminiscences
Whiffenpoofs

Friday, May 4, 2001
12:30-1:30 p.m.	Registration and Reception Lobby, Davies Auditorium, 15 Prospect Street
1:45 p.m.	Welcome - Thomas A. Steitz, Yale University Davies Auditorium, 15 Prospect Street
2:00 p.m.	Convene Session I - Greg Van Duyne, Session Chair
2:15 - 2:45 p.m.	Structure and Mechanism in G protein Signaling Steve Sprang, University of Texas Southwestern Medical Center
2:45 - 3:15 p.m.	The Structure of trp Repressor in an Inebriated State Catherine Lawson, Rutgers University
3:15 - 3:45 p.m.	The Multifunctional Arginine Repressor Greg Van Duyne, University of Pennsylvania School of Medicine
3:45 - 4:15 p.m.	Coffee Break
4:15 - 4:45 p.m.	Proteins Off, On and Around DNA Brian Matthews, University of Oregon
4:45 - 5:15 p.m.	DNA Target Discrimination by Papillomavirus E2 Proteins Rashmi Hegde, Skirball Institute for Biomolecular Medicine
5:15 p.m.	Adjourn Session I
6:00 p.m.	Cocktails/Buffet Dinner Omni Hotel, 155 Temple Street

Saturday, May 5, 2001
8:30 a.m.	Buffet Continental Breakfast Lobby, Davies Auditorium, 15 Prospect Street
9:00 a.m.	Convene Session II - Andrzej Joachimiak, Session Chair
9:15 - 9:45 a.m.	HIV-1 Integrase. The Third Enzyme of HIV David Davies, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
9:45 - 10:15 a.m.	Dynamic Features of PKA Structure and Localization Susan Taylor, University of California, San Diego
10:15 - 10:45 a.m.	Significance of Being Precise in Crystallography Zbyszek Otwinowski, University of Texas Southwestern Medical Center
10:45 - 11:15 a.m.	Coffee Break
11:15 - 11:45 a.m.	X-rays with Brilliance and Bang: 3rd Generation Synchrotrons in the Post Genomic Era Andrzej Joachimiak, Argonne National Laboratory
11:45 - 12:15 p.m.	Protein Structure by High Resolution Electron Microscopy Richard Henderson, MRC Laboratory of Molecular Biology
12:30 p.m.	Lunch Yale Commons, 168 Grove Street (enter through Woolsey Hall)
2:00 p.m.	Convene Session III - Joe Noel, Session Chair
2:15 - 2:45 p.m.	Ideas as to Why Our Brain Tires in the Evening Steve McKnight, University of Texas Southwestern Medical Center
2:45 - 3:15 p.m.	Structural and Functional Basis for Plant Biosynthetic Cascades Involved in Stress Responses Joe Noel, The Salk Institute for Biological Studies
3:15 - 3:45 p.m.	Structure and Function of Phospholipase A2 Edward Dennis, University of California, San Diego
3:45 p.m.	Coffee Break
4:15 - 4:45 p.m.	Prion Proteins -- A New Paradigm in Genetics Susan Lindquist, University of Chicago
4:45 - 5:15 p.m.	GroEL-Mediated Protein Folding Arthur Horwich, Yale University
5:15 p.m.	Adjourn Session III
6:30 p.m.	Cocktails Lorrico Ballroom, Yale Room, LoRicco Building, 216 Crown Street
7:30 p.m.	Banquet Lorrico Ballroom, LoRicco Building, 216 Crown Street Personal Reminiscences Whiffenpoofs