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Last Modified: Tuesday, 17-Feb-2009 14:17:52 EST
The image is a ribbons drawing of ribonuclease-S. This was the first protein structure determined at Yale and the third protein structure determined by X-ray diffraction of crystals after myoglobin and lysozyme.
The effort to solve the ribonuclease-S structure was spearheaded by Hal Wyckoff and Fred Richards (Wyckoff, H.W. Hardman, K.D., Allewell N.M., Inagami, T., Johnson, L.N. Richards, F.M. (1967) J. Biol. Chem. 242:3984-3988). [The ribbons drawing was made with the program, RIBBONS, by M. Carson.]
In order to facilitate the determination of macromolecular structures such
as ribonuclease above the WERMS group was formed in the
Department of Molecular Biophysics and Biochemistry at Yale University in
1976. The original Principal Investigators of this group were
Harold Wyckoff, Donald Engelman, Frederick Richards, Peter Moore and Thomas Steitz.
In 1986 the Center for Structural Biology was formally created, including the original WERMS labs, HHMI-supported
labs, and other Principal Investigators engaged in work related to structural biology.
In 2009, the CSB was subsumed in the newly-created Richards Center, named in honor of
Frederic M. Richards.
Last Modified: Tuesday, 17-Feb-2009 14:17:52 EST
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