Pat Fleming - Surface Analysis of Macromolecules



Buried Hydrophobic Surface upon Protein Folding

• Protein Stability ~ Buried Hydrophobic Surface
  
  Eisenberg,D. and McLachlan,A.D. (1986) Nature 319, 199

• ~50% of solvent surface is hydrophobic
  
  Lee, B. and Richards, F.M. (1971) J. Mol. Biol. 55,379