The Bass Center Rm 430, 266 Whitney Ave, New Haven, Connecticut 06520, USA.
Phone: +1 203 432 4330 FAX: +1 203 432 1296
E-mail: yorgo.modis@yale.edu
Nationalities: Greece, Switzerland, United States of America.
Education
1999-2000 Awarded postdoctoral fellowships by the Human Frontier Science Program Organization, the European Molecular Biology Organization (EMBO), the Swiss National Science Foundation, and the Roche Research Foundation.
1999 Ph.D. degree from the University of Leeds for work done at the European Molecular Biology Laboratory (EMBL) as a member of the EMBL PhD. Programme.
1995 First Class Honours Bachelor's degree in Biochemistry at the University of Cambridge.
1995 Kareen Thorne Prize in Biological Sciences by Trinity Hall (University of Cambridge).
1995 Bateman Scholarship by Trinity Hall (University of Cambridge).
1992 Top grade (7/7) in all six subjects of the International Baccalaureate at the International School of Geneva.
Ryuta Kanai, Kalipada Kar, Karen Anthony, L. Hannah Gould, Michel Ledizet, Erol Fikrig, Wayne A. Marasco, Ray A. Koski and Yorgo Modis (2006). Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes. J. Virol., 80, 11000-8.
Yorgo Modis, Steven Ogata, David Clements and Stephen C. Harrison (2005). Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J. Virol., 79, 1223-31.
Yorgo Modis, Steven Ogata, David Clements and Stephen C. Harrison (2004). Structure of the dengue virus envelope protein after membrane fusion. Nature, 427, 313-319.
Bert van den Berg, William M. Clemons Jr., Ian Collinson, Yorgo Modis, Enno Hartmann, Stephen C. Harrison and Tom A. Rapoport (2004). X-ray structure of a protein-conducting channel. Nature, 427, 36-44.
Yorgo Modis, Steven Ogata, David Clements and Stephen C. Harrison (2003). A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc. Natl. Acad. Sci. U.S.A., 100, 6986-6991.
Yorgo Modis, Benes L. Trus and Stephen C. Harrison (2002). An atomic model of the papillomavirus capsid. EMBO J., 21, 4754-4762.
Werner Boll, Iris Rapoport, Christian Brunner, Yorgo Modis, Siegfried Prehn and Tomas Kirchhausen (2002). The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and Ypp0 sorting signals at distinct sites. Traffic, 3, 590-600.
Anu M. Mursula, Daan M.F. van Aalten, Yorgo Modis, J. Kalervo Hiltunen and Rik K. Wierenga (2000). Crystallization and X-ray diffraction analysis of peroxisomal delta3-delta2-enoyl-CoA isomerase from Saccharomyces cerevisiae. Acta Crystallogr. D, 56, 1020-1023.
Yorgo Modis and Rik K. Wierenga (2000). Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. J. Mol. Biol., 297, 1171-1182.
Yorgo Modis and Rik K. Wierenga (1999). A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism. Structure Fold Des., 7, 1279-1290.
Yorgo Modis (1999). Structural studies of enzymes in the beta-oxidation pathway. Ph.D. Thesis. European Molecular Biology Laboratory and University of Leeds.
Yorgo Modis & Rik Wierenga (1998). Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes. Structure, 6, 1345-1350.
Yorgo Modis, Sirpa A. Filppula, Dmitri K. Novikov, Brian Norledge, J. Kalervo Hiltunen, and Rik K. Wierenga (1998). The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate side chains for catalysis. Structure, 6, 957-970.
Magali Mathieu, Yorgo Modis, Johan Ph. Zeelen, Christian K. Engel, Ruben A. Abagyan, Anders Ahlberg, Bjarne Rasmussen, Victor Lamzin, Wolf H. Kunau & Rik Wierenga (1997). The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. J. Mol. Biol., 273, 714-728.
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. University of Geneva, Department of Molecular Biology, Switzerland (July 20th, 2004).
Structures of the dengue virus envelope protein before and after membrane fusion. Medical Grand Rounds. The Children's Hospital, Boston, USA (June 9th, 2004).
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. University of Washington, Department of Biochemistry, USA (February 23rd, 2004).
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. University of Oxford, Department of Biochemistry, UK (February 6th, 2004).
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. Massachusetts Institute of Technology, Department of Biology, Cambridge, USA (January 20th, 2004).
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, USA (January 12th, 2004).
Molecular mechanisms of virus assembly and viral entry into cells: Structural insights from papillomavirus and dengue virus. Cancer Research UK Lincoln's Inn Fields, London, UK (December 17th, 2003).
Structures of dengue virus envelope glycoprotein before and after membrane fusion. Cancer Research UK Lincoln's Inn Fields, London, UK (July 4th, 2003).
A ligand-binding pocket in the dengue virus envelope glycoprotein. Gordon Research Conference: Viruses and Cells. Il Ciocco, Italy (May 19th, 2003).
LANGUAGES
Skiing, flying, swimming and cycling. Travel.