ROSETTA++

The first close to atomic-level resolution,
blind ab initio structure prediction: CASP6 T281
Image: Dr. Phil Bradley

Rosetta++ is a software suite for the prediction and design of protein structures, protein folding mechanisms, and protein-protein interactions. The Rosetta codes have been repeatedly successful in the Critical Assessment of Techniques for Protein Structure Prediction (CASP) competition as well as the CAPRI competition and have been modified to address additional aspects of protein design, docking and structure.

To get started:

setup rosetta

There is skimpy local documentation available.

Further documentation is available from the Rosetta Design Group Wiki.