SHARP is a computer program for macromolecular crystallography. It operates on reduced, merged and scaled data from SIR(AS), MIR(AS) and MAD experiments, refines the heavy-atom model, helps detect minor or disordered sites using likelihood-based residual maps, and calculates phase probability distributions for all reflexions in the dataset.

The new version of SHARP includes the following features:

• autoSHARP: a fully automated structure solution system - from merged data to automatic model building (uses SHARP as phasing engine).
• interface to ARP/wARP (see www.arp-warp.org) from SHARP output.

Existing features have been extensively improved:

• the heavy atom refinement and phasing in SHARP is more robust and powerful
• density modification protocols are significantly improved
• allows use of a single server for submission of jobs to a heterogeneous cluster of machines
• new documentation and tutorials are also completely rewritten

To use SHARP please ask Shanti Kunchaparty to create a user account for you (available for CSB users only).
SHARP runs from within a browser (here netscape) and requires that over 2MB of SHARP environment files be deposited in your working directory. 
To access the SHARP environment you will need a special user ID and password.

Once you have obtained these just type (from a CSB computer):

netscape http://bhima:8080

To see what this is all about, CSB core members (only) may browse the manual and tutorials.
Sample files may be copied to the user's sharpfiles directory from /srv/local/sharp/samples/sharp/

The Sharp home page has FAQs and release notes.