SHARP is a computer program for macromolecular crystallography. It operates on reduced, merged and scaled data from SIR(AS), MIR(AS) and MAD experiments, refines the heavy-atom model, helps detect minor or disordered sites using likelihood-based residual maps, and calculates phase probability distributions for all reflexions in the dataset.

The new version of SHARP includes the following features:

• autoSHARP: a fully automated structure solution system - from merged data to automatic model building (uses SHARP as phasing engine).
• interface to ARP/wARP (see www.arp-warp.org) from SHARP output.

Existing features have been extensively improved:

• the heavy atom refinement and phasing in SHARP is more robust and powerful
• density modification protocols are significantly improved
• allows use of a single server for submission of jobs to a heterogeneous cluster of machines
• new documentation and tutorials are also completely rewritten

To use SHARP please ask Shanti Kunchaparty to create a user account for you (available for CSB users only).
SHARP runs from within a browser (here netscape) and requires that over 2MB of SHARP environment files be deposited in your working directory. 
To access the SHARP environment you will need a special user ID and password.

Sharp is now available (in the CSB core) on emperor.core (linux) in an interactive mode and on bhima.core where the jobs get submitted to the available batch queues in the core.

To run Sharp on emperor type:
netscape http://emperor:8080
You will first need to make sure that another user is not running sharp on emperor

To run Sharp on bhima type:
netscape http://bhima:8080
You will be able to submit the sharp jobs to the batch queues.

To see what this is all about, CSB core members (only) may browse the manual and tutorials.
Sample files may be copied to the user's sharpfiles directory from /srv/local/sharp/samples/sharp/

The Sharp home page has FAQs and release notes.